SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990.Right pointing arrow large image Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public Inspection
Name of the organization
MAYO CLINIC
 
Employer identification number

41-6011702
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in the region (d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in the region
(f) Total expenditures
for and investments
in the region
CENTRAL AMERICA AND THE CARIBBEAN 0 1 TRAVEL   4,004
EAST ASIA AND THE PACIFIC 0 1 TRAVEL   180
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 16 TRAVEL   56,292
MIDDLE EAST AND NORTH AFRICA 0 10 TRAVEL   72,184
NORTH AMERICA 0 7 TRAVEL   29,196
RUSSIA AND THE NEIGHBORING STATES 0 0 TRAVEL    
SOUTH AMERICA 0 4 TRAVEL   12,048
SOUTH ASIA 0 1 TRAVEL   2,200
SUB-SAHARAN AFRICA 0 1 TRAVEL   681
EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES PATIENT CARE  
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 5 PROGRAM SERVICES PATIENT CARE 109,998
MIDDLE EAST AND NORTH AFRICA 0 4 PROGRAM SERVICES PATIENT CARE 553,366
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 2 PROGRAM SERVICES RESEARCH 186,766
NORTH AMERICA 0 0 PROGRAM SERVICES EDUCATION CONFERENCE - MAYO SPONSOR  
CENTRAL AMERICA AND THE CARIBBEAN 0 0 INVESTMENTS   969,346,159
EAST ASIA AND THE PACIFIC 0 0 INVESTMENTS   1,343,845,528
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 0 INVESTMENTS EXPENSE   14,423,325
EUROPE (INCLUDING ICELAND AND GREENLAND) 1 0 INVESTMENTS   753,013,160
MIDDLE EAST AND NORTH AFRICA 0 0 INVESTMENTS   119,173,074
NORTH AMERICA 0 0 INVESTMENTS   105,337,256
RUSSIA AND THE NEIGHBORING STATES 0 0 INVESTMENTS   3,420,706
SOUTH AMERICA 0 0 INVESTMENTS   6,400,110
SOUTH ASIA 0 0 INVESTMENTS   66,308,371
SUB-SAHARAN AFRICA 0 0 INVESTMENTS   2,967,516
EAST ASIA AND THE PACIFIC 1 6 UNRELATED BUSINESS ACTIVITY REFERENCE LAB SALES & MARKETING 792,623
EUROPE (INCLUDING ICELAND AND GREENLAND) 0 1 UNRELATED BUSINESS ACTIVITY REFERENCE LAB SALES & MARKETING  
MIDDLE EAST AND NORTH AFRICA 0 4 UNRELATED BUSINESS ACTIVITY REFERENCE LAB SALES & MARKETING 1,001,328
NORTH AMERICA 0 8 UNRELATED BUSINESS ACTIVITY REFERENCE LAB SALES & MARKETING 1,204,330
SOUTH AMERICA 0 4 UNRELATED BUSINESS ACTIVITY REFERENCE LAB SALES & MARKETING 37,837
3a Sub-total .... 0 40 176,104
b Total from continuation sheets to Part I ... 2 35 3,388,122,134
c Totals (add lines 3a and 3b) 2 75 3,388,298,238
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)
(c) Region (d) Purpose of
grant
(e) Amount of
cash grant
(f) Manner of
cash
disbursement
(g) Amount
of noncash
assistance
(h) Description
of noncash
assistance
(i) Method of
valuation
(book, FMV,
appraisal, other)
EAST ASIA AND THE PACIFIC   140   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   101,216   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   40,446   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   57,778   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   265,316   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   85,904   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   90,856   0    
EAST ASIA AND THE PACIFIC   29,400   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   91,638   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   86,980   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   21,355   0    
NORTH AMERICA   7,500   0    
SOUTH ASIA   55,944   0    
NORTH AMERICA   700   0    
EAST ASIA AND THE PACIFIC   124,871   0    
EAST ASIA AND THE PACIFIC   23,822   0    
NORTH AMERICA   200   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   150,000   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   192,384   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   288,798   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   84,000   0    
NORTH AMERICA   50,243   0    
NORTH AMERICA   203,097   0    
NORTH AMERICA   5,040   0    
EUROPE (INCLUDING ICELAND & GREENLAND)   92,233   0    
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
0
3 Enter total number of other organizations or entities .......................MediumBullet
25
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant
(e) Manner of cash
disbursement
(f) Amount of
noncash
assistance
(g) Description
of noncash
assistance
(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
ReturnReference Explanation
PART I, LINE 2: FEDERAL AWARDS THAT ARE SUBCONTRACTED TO OTHER ORGANIZATIONS ARE REGULARLY MONITORED BY THE FILING ORGANIZATION FOR COMPLIANCE WITH EITHER THE FEDERAL REGULATIONS AND/OR THE CONTRACT PROVISIONS. SEE ALSO SCHEDULE I, PART IV FOR ADDITIONAL INFORMATION ON MAYO CLINIC'S PROCEDURES FOR MONITORING THE USE OF GRANT FUNDS AS THE SAME PROCEDURES APPLY TO DOMESTIC AND FOREIGN GRANTS. GENERAL INFORMATION ON ACTIVITIES OUTSIDE THE UNITED STATES IS REPORTED BASED ON WHERE PAYMENTS WERE REMITTED. OUR CURRENT REPORTING SYSTEM DOES NOT TRACK ACTIVITIES OUTSIDE THE UNITED STATES BY LOCATION OF SERVICE.
PART I, LINE 3: ACCRUAL METHOD
PART III ACCOUNTING METHOD:  
PART IV - FILING OF CERTAIN FOREIGN FORMS DISCLOSURE STATEMENT RELATED TO FORMS 5713: FORM 5713 HAS BEEN FILED BY THE FOLLOWING MEMBERS OF THE CONTROLLED GROUP: MAYO CLINIC (EIN: 41-6011702) MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (EIN: 41-1506440) MAYO CLINIC HEALTH SYSTEM - NORTHWEST WISCONSIN REGION, INC. (EIN: 39-0813418) DISCLOSURE STATEMENT RELATED TO FORMS 5471: UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B), THE TAXPAYER IS REQUIRED TO FILE FORMS 5471, INFORMATION RETURN OF U.S. PERSONS WITH RESPECT TO CERTAIN FOREIGN CORPORATIONS, AS A CATEGORY 4 AND 5 FILER WITH RESPECT TO THE CONTROLLED FOREIGN CORPORATIONS (CFCS). THESE FILING REQUIREMENTS ARE OR WILL BE SATISFIED THROUGH THE FILING OF FORMS 5471 FOR THESE CFCS BY OTHER U.S. TAXPAYERS IDENTIFIED BELOW WHO HAVE THE SAME FILING REQUIREMENT. TAXPAYER NAME: MAYO CLINIC ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 5471 WAS FILED: 41-6011702 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT TAXPAYER NAME: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 5471 WAS FILED: 41-1506440 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT DISCLOSURE STATEMENT RELATED TO FORMS 8865: UNDER THE CONSTRUCTIVE OWNERSHIP RULES OF IRC SECTIONS 958(A) AND (B), THE TAXPAYER IS REQUIRED TO FILE FORMS 8865, INFORMATION RETURN OF U.S. PERSONS WITH RESPECT TO CERTAIN FOREIGN PARTNERSHIPS (CFPS), AS A CATEGORY 2 AND 3 FILER. THESE FILING REQUIREMENTS ARE OR WILL BE SATISFIED THROUGH THE FILING OF FORMS 8865 FOR THESE PARTNERSHIPS BY OTHER U.S. TAXPAYERS IDENTIFIED BELOW WHO HAVE THE SAME FILING REQUIREMENT. TAXPAYER NAME: MAYO CLINIC ADDRESS: 200 FIRST STREET SW, ROCHESTER, MN 55905 ID NUMBER OF U.S. TAX RETURN WITH FORMS 8865 WAS FILED: 41-6011702 IRS SERVICE CENTER WHERE U.S. TAX RETURN WAS OR WILL BE FILED: OGDEN, UT
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2021
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