SCHEDULE F(Form 990)
Department of the Treasury
Internal Revenue Service
Statement of Activities Outside the United States
Right pointing arrow large image Complete if the organization answered "Yes" to Form 990, Part IV, line 14b, 15, or 16.Right pointing arrow large image Attach to Form 990.Right pointing arrow large image Go to www.irs.gov/Form990 for instructions and the latest information.
OMB No. 1545-0047
2021
Open to Public Inspection
Name of the organization
CYSTIC FIBROSIS FOUNDATION
 
Employer identification number

13-1930701
Part I
General Information on Activities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 14b.
1
For grantmakers. Does the organization maintain records to substantiate the amount of its grants and
other assistance, the grantees’ eligibility for the grants or assistance, and the selection criteria used
to award the grants or assistance? . . . . . . . . . . . . . . . . . . . . . . . . .
2
For grantmakers. Describe in Part V the organization’s procedures for monitoring the use of its grants and other assistance outside the United States.
3
Activites per Region. (The following Part I, line 3 table can be duplicated if additional space is needed.)
(a) Region (b) Number of offices in the region (c) Number of employees, agents, and independent contractors in the region (d) Activities conducted in region (by type) (such as, fundraising, program services, investments, grants to recipients located in the region) (e) If activity listed in (d) is a program service, describe specific type of
service(s) in the region		 (f) Total expenditures
for and investments
in the region
EUROPE 0 0 GRANTMAKING NONE 6,548,200
NORTH AMERICA 0 0 GRANTMAKING NONE 4,243,804
EAST ASIA AND THE PACIFIC 0 0 GRANTMAKING NONE 2,971,365
MIDDLE EAST AND NORTH AFRICA 0 0 GRANTMAKING NONE 274,002
CENTRAL AMERICA & CARIBBEAN 0 0 INVESTMENTS   888,060,000
EAST ASIA & PACIFIC 0 0 INVESTMENTS   183,767,000
EUROPE 0 0 INVESTMENTS   387,207,000
NORTH AMERICA 0 0 INVESTMENTS   68,076,000
MIDDLE EAST AND NORTH AFRICA 0 0 INVESTMENTS   2,195,000
NORTH AMERICA 0 0 PROGRAM SERVICES CONTRACTED RESEARCH 1,255,502
MIDDLE EAST AND NORTH AFRICA 0 0 PROGRAM SERVICES CONTRACTED RESEARCH 688,716
EUROPE 0 0 PROGRAM SERVICES CONTRACTED RESEARCH 495,704
EAST ASIA AND THE PACIFIC 0 0 PROGRAM SERVICES CONTRACTED RESEARCH 200,000
SOUTH ASIA 0 0 PROGRAM SERVICES CONTRACTED RESEARCH 175,000
           
           
           
3a Sub-total .... 0 0 1,541,147,371
b Total from continuation sheets to Part I ... 0 0 5,009,922
c Totals (add lines 3a and 3b) 0 0 1,546,157,293
For Paperwork Reduction Act Notice, see the Instructions for Form 990.Cat. No. 50082W Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 2
Part II
Grants and Other Assistance to Organizations or Entities Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 15, for any recipient who received more than $5,000. Part II can be duplicated if additional space is needed.
1 (a) Name of organization (b) IRS code section
and EIN (if applicable)		 (c) Region (d) Purpose of
grant 		(e) Amount of
cash grant 		(f) Manner of
cash
disbursement 		(g) Amount
of noncash
assistance 		(h) Description
of noncash
assistance 		(i) Method of
valuation
(book, FMV,
appraisal, other)
EUROPE RESEARCH 144,701 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH STUDY 488,600 WIRE 0    
NORTH AMERICA THERAPEUTICS DISCOVERY RESEARCH 64,864 WIRE 0    
EUROPE CLINICAL RESEARCH CENTER 443,264 WIRE 0    
EUROPE QUALITY IMPROVEMENT 819,368 WIRE 0    
EUROPE THERAPEUTICS DISCOVERY RESEARCH 199,876 WIRE 0    
EUROPE CLINICAL RESEARCH CENTER 1,410,608 WIRE 0    
EUROPE PILOT STUDY 56,000 WIRE 0    
EUROPE PILOT STUDY 109,749 WIRE 0    
EUROPE RESEARCH 280,000 WIRE 0    
EUROPE CLINICAL RESEARCH STUDY 414,719 WIRE 0    
EUROPE RESEARCH 132,300 WIRE 0    
EUROPE RESEARCH 139,948 WIRE 0    
EUROPE CLINICAL RESEARCH STUDY 102,810 WIRE 0    
NORTH AMERICA RESEARCH 692,840 WIRE 0    
EUROPE PILOT STUDY 55,999 WIRE 0    
MIDDLE EAST AND NORTH AFRICA CLINICAL RESEARCH 52,920 WIRE 0    
EUROPE RESEARCH 140,000 WIRE 0    
EUROPE ADHERENCE 223,023 WIRE 0    
EUROPE THERAPEUTICS DISCOVERY RESEARCH 220,018 WIRE 0    
EAST ASIA AND THE PACIFIC RESEARCH 139,581 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH 515,675 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH STUDY 270,608 WIRE 0    
NORTH AMERICA RESEARCH STUDY 63,350 WIRE 0    
MIDDLE EAST AND NORTH AFRICA CLINICAL RESEARCH 81,189 WIRE 0    
MIDDLE EAST AND NORTH AFRICA RESEARCH 139,893 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH CENTER 149,365 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH STUDY 377,654 WIRE 0    
NORTH AMERICA RESEARCH 139,946 WIRE 0    
NORTH AMERICA THERAPEUTICS DISCOVERY RESEARCH 120,500 WIRE 0    
EUROPE RESEARCH 45,000 WIRE 0    
NORTH AMERICA PILOT STUDY 56,000 WIRE 0    
EUROPE CLINICAL RESEARCH 782,469 WIRE 0    
EUROPE RESEARCH 229,729 WIRE 0    
EAST ASIA AND THE PACIFIC RESEARCH 139,977 WIRE 0    
EAST ASIA AND THE PACIFIC PILOT STUDY 89,583 WIRE 0    
EAST ASIA AND THE PACIFIC CLINICAL RESEARCH 651,209 WIRE 0    
EAST ASIA AND THE PACIFIC CLINICAL RESEARCH STUDY 1,672,505 WIRE 0    
EAST ASIA AND THE PACIFIC PILOT STUDY 55,442 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH STUDY 164,074 WIRE 0    
EUROPE RESEARCH 119,850 WIRE 0    
EUROPE RESEARCH 278,976 WIRE 0    
NORTH AMERICA CLINICAL CARE RESEARCH 829,440 WIRE 0    
NORTH AMERICA CLINICAL RESEARCH STUDY 168,000 WIRE 0    
NORTH AMERICA RESEARCH 139,888 WIRE 0    
EUROPE PILOT STUDY 82,901 WIRE 0    
EAST ASIA AND THE PACIFIC CLINICAL RESEARCH 223,068 WIRE 0    
2 Enter total number of recipient organizations listed above that are recognized as charities by the foreign country, recognized as tax-exempt by the IRS, or for which the grantee or counsel has provided a section 501(c)(3) equivalency letter .......MediumBullet
33
3 Enter total number of other organizations or entities .......................MediumBullet
0
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021Page 3
Part III
Grants and Other Assistance to Individuals Outside the United States. Complete if the organization answered "Yes" on Form 990, Part IV, line 16.
Part III can be duplicated if additional space is needed.
(a) Type of grant or assistance (b) Region (c) Number of recipients (d) Amount of
cash grant 		(e) Manner of cash
disbursement 		(f) Amount of
noncash
assistance 		(g) Description
of noncash
assistance 		(h) Method of
valuation
(book, FMV,
appraisal, other)
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
               
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 4
Part IV
Foreign Forms
1 Was the organization a U.S. transferor of property to a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 926, Return by a U.S. Transferor of Property to a Foreign Corporation (see Instructions for Form 926). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
2 Did the organization have an interest in a foreign trust during the tax year? If "Yes," the organization may be required to separately file Form 3520, Annual Return to Report Transactions with Foreign Trusts and Receipt of Certain Foreign Gifts, and/or Form 3520-A, Annual Information Return of Foreign Trust With a U.S. Owner (see Instructions for Forms 3520 and 3520-A; don't file with Form 990). . . . . . . . . . . . . . . . . . . . . . . .
3 Did the organization have an ownership interest in a foreign corporation during the tax year? If "Yes," the organization may be required to file Form 5471, Information Return of U.S. Persons with Respect to Certain Foreign Corporations. (see Instructions for Form 5471). . . . . . . . . . . . . . . . . . . . . . . . . . . .
4 Was the organization a direct or indirect shareholder of a passive foreign investment company or a qualified electing fund during the tax year? If “Yes,” the organization may be required to file Form 8621, Information Return by a Shareholder of a Passive Foreign Investment Company or Qualified Electing Fund. (see Instructions for Form 8621) .
5 Did the organization have an ownership interest in a foreign partnership during the tax year? If "Yes," the organization may be required to file Form 8865, Return of U.S. Persons with Respect to Certain Foreign Partnerships (see Instructions for Form 8865). . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
6 Did the organization have any operations in or related to any boycotting countries during the tax year? If "Yes," the organization may be required to separately file Form 5713, International Boycott Report (see Instructions for Form 5713; don't file with Form 990).. . . . . . . . . . . . . . . . . . . . . . . . . . . .
Schedule F (Form 990) 2021
Schedule F (Form 990) 2021
Page 5
Part V
Supplemental Information
Provide the information required by Part I, line 2 (monitoring of funds); Part I, line 3, column (f) (accounting method; amounts of investments vs. expenditures per region); Part II, line 1 (accounting method); Part III (accounting method); and Part III, column (c) (estimated number of recipients), as applicable. Also complete this part to provide any additional information. See instructions.
ReturnReference Explanation
PART III ACCOUNTING METHOD:  
SCHEDULE F, PART IV: PROCEDURES FOR MONITORING GRANT FUNDS OUTSIDE OF THE U.S. THE ORGANIZATION HAS PROCEDURES IN PLACE TO MONITOR THE SCIENTIFIC PROGRESS AND FINANCIAL ASPECTS OF GRANTS AWARDED TO ENTITIES OUTSIDE OF THE UNITED STATES. THE ORGANIZATION FOLLOWS THE U.S. DEPARTMENT OF TREASURY ANTI-TERRORIST FINANCING VOLUNTARY BEST PRACTICES GUIDELINES FOR CHARITIES. IN COMPLIANCE WITH THE BEST PRACTICES, THE ORGANIZATION COLLECTS AND REVIEWS INFORMATION ABOUT THE PROSPECTIVE GRANTEES AND CONDUCTS A VETTING PROCESS TO ENSURE THEY ARE NOT SUSPECTED OF ACTIVITIES RELATED TO TERRORISM. ONCE A GRANT IS APPROVED, A WRITTEN AGREEMENT IS SIGNED BY BOTH THE ORGANIZATION AND THE GRANTEE. FUNDING IS INCREMENTAL AND SPONSORED INSTITUTIONS ARE REQUIRED TO SUBMIT ANNUAL REPORTS OF EXPENDITURES AS WELL AS SCIENTIFIC PROGRESS REPORTS. SCIENTIFIC REPORTS ARE REVIEWED BY THE ORGANIZATION'S SCIENTIFIC STAFF TO DETERMINE PROGRESS. THE FINAL GRANT PAYMENT IS CONTINGENT UPON RECEIPT AND APPROVAL OF THE REPORT OF EXPENDITURES AND THE FINAL SCIENTIFIC REPORT. REPORTS OF EXPENDITURES ARE REVIEWED AND APPROVED BY STAFF TO ENSURE INCURRED COSTS ARE APPROPRIATE. THE GRANTS TO THE MIDDLE EAST/NORTH AFRICA REGION WERE MADE TO THE RESEARCH FUND OF THE HADASSAH MEDICAL ORGANIZATION AND THE HEBREW UNIVERSITY OF JERUSALEM IN ISRAEL. FOREIGN FORMS - INVESTMENTS THE ACTIVITIES REFERENCED IN SCHEDULE F, PART IV ARE LIMITED TO CERTAIN OF THE FOUNDATION'S INVESTMENTS.
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
   
Schedule F (Form 990) 2021
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